Sertraline
Mechanism
Selectively inhibits serotonin reuptake in the central nervous system, increasing serotonergic activity.
Uses
- Major depressive disorder
- Obsessive compulsive disorder
- Panic disorder
- Posttraumatic stress disorder
- Social anxiety disorder
Common effects
- Nausea
- Diarrhea
- Insomnia or somnolence
- Sexual dysfunction
Serious risks
- Suicidal thoughts and behaviors in younger patients
- Serotonin syndrome
- Hyponatremia
- Abnormal bleeding
Monitoring
- Mood and suicidal thinking
- Activation or mania
- Sodium when clinically indicated
- Serotonergic and bleeding interactions
Counseling
- Benefit may take several weeks
- Do not stop abruptly
- Review serotonergic medicines and supplements
- Oral concentrate requires product specific dilution