Semaglutide
Mechanism
Activates GLP-1 receptors, increasing glucose dependent insulin secretion, reducing glucagon secretion, slowing gastric emptying, and influencing appetite.
Uses
- Type 2 diabetes mellitus with product specific benefits
- Chronic weight management with indicated products
- Cardiovascular risk reduction with indicated products
Common effects
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Abdominal pain
Serious risks
- Boxed warning for thyroid C-cell tumors
- Pancreatitis
- Gallbladder disease
- Kidney injury related to volume depletion
- Diabetic retinopathy complications in susceptible patients
Monitoring
- Glucose and A1C when used for diabetes
- Gastrointestinal tolerance and hydration
- Weight when relevant
- Vision changes and symptoms of pancreatitis or gallbladder disease
Counseling
- Brand indications and administration instructions are not interchangeable
- Follow the product specific titration plan
- Report severe persistent abdominal pain
- Discuss pregnancy plans well before treatment