Omeprazole
Mechanism
Irreversibly inhibits the gastric parietal cell hydrogen potassium ATPase, suppressing acid secretion.
Uses
- Gastroesophageal reflux disease
- Erosive esophagitis
- Peptic ulcer disease
- Helicobacter pylori treatment regimens
Common effects
- Headache
- Abdominal pain
- Nausea
- Diarrhea
Serious risks
- Clostridioides difficile associated diarrhea
- Hypomagnesemia
- Acute tubulointerstitial nephritis
- Long term nutrient and fracture concerns
Monitoring
- Symptom response and ongoing indication
- Magnesium when prolonged therapy or risk factors warrant
- Renal symptoms
- Long term treatment necessity
Counseling
- Take before meals when directed
- Do not crush or chew delayed release units
- Use the shortest appropriate duration
- Report persistent diarrhea or reduced urine output