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Fluoxetine

ProzacSelective serotonin reuptake inhibitorCapsule, tablet, and oral solution

Fluoxetine 20 mg capsule

Example product · E 91
Strength20 mg
FormHard gelatin capsule
ColorGreen and off-white
ImprintE · 91

This is one labeled manufacturer presentation. Fluoxetine products can have different colors, shapes, and imprints. Confirm the imprint and original packaging rather than relying on color.

View the source label on DailyMed ↗

Mechanism

Selectively inhibits serotonin reuptake in the central nervous system, increasing serotonergic activity.

Uses

  • Major depressive disorder
  • Obsessive compulsive disorder
  • Panic disorder
  • Bulimia nervosa

Common effects

  • Nausea
  • Insomnia or somnolence
  • Headache
  • Sexual dysfunction

Serious risks

  • Suicidal thoughts and behaviors in younger patients
  • Serotonin syndrome
  • Hyponatremia
  • Abnormal bleeding

Monitoring

  • Mood and suicidal thinking
  • Activation or mania
  • Sodium when clinically indicated
  • Serotonergic and bleeding interactions

Counseling

  • Benefit may take several weeks
  • Do not stop without a planned discussion
  • Report agitation, fever, confusion, or severe restlessness
  • Review all serotonergic medicines and supplements
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