Apixaban
Mechanism
Selectively inhibits factor Xa, reducing thrombin generation and clot formation.
Uses
- Stroke prevention in nonvalvular atrial fibrillation
- Treatment of deep vein thrombosis and pulmonary embolism
- Prevention of recurrent venous thromboembolism
Common effects
- Bleeding
- Bruising
- Nausea
- Anemia
Serious risks
- Major bleeding
- Thrombotic risk after premature discontinuation
- Spinal or epidural hematoma
- Important interaction related bleeding risk
Monitoring
- Bleeding and bruising
- Complete blood count
- Renal and hepatic function
- Adherence and interacting medicines
Counseling
- Do not stop without a prescriber plan
- Take missed doses according to the current label
- Report unusual or persistent bleeding
- Tell every clinician and dentist that you take an anticoagulant